{"id":2565,"date":"2024-12-04T12:50:00","date_gmt":"2024-12-04T20:50:00","guid":{"rendered":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/?p=2565"},"modified":"2025-02-19T13:21:32","modified_gmt":"2025-02-19T21:21:32","slug":"molecular-biology-institute-seminar-series-dr-yiqun-wang","status":"publish","type":"post","link":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/molecular-biology-institute-seminar-series-dr-yiqun-wang\/","title":{"rendered":"Molecular Biology Institute Seminar Series: Dr. Yiqun Wang"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Upcoming Seminar<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full is-style-rounded\"><img decoding=\"async\" src=\"https:\/\/biology.sdsu.edu\/wp-content\/uploads\/2024\/12\/yiqun-wang-300.jpg\" alt=\"Closeup of Yiqun Wang\" class=\"wp-image-3166\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\"><strong>Title<\/strong><\/h3>\n\n\n\n<p><strong>Spatial Transcriptomic Teconstruction of Spiralian Embryonic Patterning<\/strong><\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\"><strong>Speaker<\/strong><\/h3>\n\n\n\n<p><strong><strong>Yiqun Wang, Ph.D.<\/strong>&nbsp;<\/strong><br><em>Postdoctoral Scholar<\/em><br>Center for Marine Biotechnology and Biomedicine<br>Scripps Institution of Oceanography <br>UC San Diego<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">Bio<\/h3>\n\n\n\n<p>Dr. Wang conducted seminal work on cellular trajectories in zebrafish embryogenesis for her doctoral research with Dr. Alex Schier (including groundbreaking studies published in&nbsp;<em>Science<\/em>&nbsp;and&nbsp;<em>Developmental Cell<\/em>). As a senior Postdoctoral scholar at Scripps Institution of Oceanography in the lab of Dr. Dede Lyons, Dr. Wang is investigating the cellular and molecular mechanisms that mollusc (snail) embryos use to determine cell fate. <\/p>\n\n\n\n<p>Her focus is on mRNA localization and asymmetric cell division in the species&nbsp;<em>Crepidula<\/em>, and how those mechanisms can be tweaked over evolutionary time scales. Her work uses a combination of spatial transcriptomics (MERFISH), live imaging, and genome editing.<\/p>\n\n\n\n<p>Dr. Wang has discovered that molluscan embryos rely heavily on localized mRNA for specification of cell fate, more so than found in fly and vertebrate embryos. Dr. Wang also recognized that to make up for the lack of decades\u2019 worth of investigation in these embryos with traditional approaches (<em>e.g<\/em>., forward screens, studying one gene or one mutant at a time), more high-throughput methods would be necessary. <\/p>\n\n\n\n<p>To this end, she initiated a collaboration with Dr. Bintu\u2019s lab at UC San Diego to adapt MERFISH to whole mount embryos to look at global patterns of mRNA localization.&nbsp; She also built many necessary tools and reagents to do this, such as assembling a comprehensive developmental transcriptome, and trouble-shooting fixation and clearing methods to make MERFISH possible. <\/p>\n\n\n\n<p>Her work is the first application of spatial transcriptomics to any whole-mount embryo.&nbsp; Dr. Wang relishes solving technical challenges and seeks out opportunities to collaborate and adapt new technologies to her research questions.&nbsp;&nbsp;<\/p>\n<\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Date<\/strong><\/h3>\n\n\n\n<p>Thursday, December 5, 2024 \u2022 4:00 PM<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">Location<\/h3>\n\n\n\n<p>BioScience Center Gold Auditorium<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\">Zoom<\/h3>\n\n\n\n<p><a href=\"https:\/\/sdsu.zoom.us\/j\/5179709840\">https:\/\/sdsu.zoom.us\/j\/5179709840<\/a><br><\/p>\n<\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Host<\/h3>\n\n\n\n<p><strong>Dr.&nbsp;Cat Schrankel<\/strong><br>Department of Biology <em>\u2022<\/em> Professor<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Spatial Transcriptomic Teconstruction of Spiralian Embryonic Patterning | December 5, 2024 \u2022 4:00 PM | Dr. Cat Schrankel<\/p>\n","protected":false},"author":6,"featured_media":2569,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2565","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts\/2565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/comments?post=2565"}],"version-history":[{"count":2,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts\/2565\/revisions"}],"predecessor-version":[{"id":2568,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts\/2565\/revisions\/2568"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/media\/2569"}],"wp:attachment":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/media?parent=2565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/categories?post=2565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/tags?post=2565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}