{"id":2620,"date":"2025-05-28T15:00:24","date_gmt":"2025-05-28T22:00:24","guid":{"rendered":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/?p=2620"},"modified":"2025-06-18T14:54:52","modified_gmt":"2025-06-18T21:54:52","slug":"alternative-nf-%ce%bab-signaling-promotes-%ce%b1v%ce%b23-mediated-stress-tolerance-and-relapse-in-high-grade-serous-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/alternative-nf-%ce%bab-signaling-promotes-%ce%b1v%ce%b23-mediated-stress-tolerance-and-relapse-in-high-grade-serous-ovarian-cancer\/","title":{"rendered":"Alternative NF-\u03baB Signaling Promotes \u03b1V\u03b23-Mediated Stress Tolerance and Relapse in High-Grade Serous Ovarian Cancer"},"content":{"rendered":"\n
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Omar Lujano Olazaba<\/strong><\/h2>\n\n\n\n

Program: <\/strong>Joint Doctoral Program in Cell & Molecular Biology
Date:<\/strong>\u00a0Thursday, May 29, 2025
Time:<\/strong> 12:00 pm
Location:<\/strong> Donald P. Shiley BioScience Center Gold Auditorium
Recording:\u00a0<\/strong>Watch defense on YouTube<\/a><\/p>\n<\/div>\n\n\n\n

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Committee Members<\/h2>\n\n\n\n
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  • Dr. Carrie D. House (Chair), SDSU<\/li>\n\n\n\n
  • Dr. Angelica Riestra, SDSU<\/li>\n\n\n\n
  • Dr. Parag Katira, SDSU<\/li>\n\n\n\n
  • Dr. David Schlaepfer, UCSD<\/li>\n\n\n\n
  • Dr. Karl Willert, UCSD<\/li>\n<\/ul>\n\n\n\n

    Abstract<\/h2>\n\n\n\n

    High-grade serous ovarian cancer  initially responds to chemotherapy but frequently relapses with chemoresistant disease, potentially driven by cancer stem-like cells (CSCs) that share many attributes with conventional stem cells.<\/p>\n\n\n\n

    TWEAK\u2013Fn14\u2013NF-\u03baB signaling regulates integrin \u03b1V\u03b23 expression on CD117\u207a ovarian CSCs, with RelA promoting ITGAV and RelB promoting ITGB3 expression, indicating roles for classical and alternative NF-\u03baB signaling. Given \u03b1V\u03b23\u2019s role in stress responses, chemotherapy resistance, and matrix adhesion, we investigated its involvement in CSC survival and tumor repopulation within chemotherapy-altered stroma.<\/p>\n\n\n\n

    Our in vitro<\/em> and in vivo<\/em> data show chemotherapy increases fibroblast vitronectin and fibronectin production and promotes TWEAK\u2013Fn14\u2013NF-\u03baB\u2013mediated \u03b1V\u03b23 expression, supporting stress-tolerant CSC survival. \u03b1V\u03b23\u207a cells exhibit greater metastatic ability in chemotherapy-altered tissues, and relapse models show enrichment of \u03b1V\u03b23\u207a cells and mesenteric growth mediated by RelB. <\/p>\n\n\n\n

    Inhibition of RelB, \u03b1V\u03b23, and \u03b1V\u03b25 during chemotherapy administration eradicates \u03b1V\u03b23\u207a stress tolerant cells, inhibits omental burden, and significantly prolongs survival, highlighting new potential therapeutic targets for ovarian cancer.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Omar Lujano Olazaba | Thursday, May 29, 2025.<\/p>\n","protected":false},"author":15,"featured_media":2649,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-2620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dissertation-cmb"],"_links":{"self":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts\/2620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/comments?post=2620"}],"version-history":[{"count":13,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts\/2620\/revisions"}],"predecessor-version":[{"id":2657,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/posts\/2620\/revisions\/2657"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/media\/2649"}],"wp:attachment":[{"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/media?parent=2620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/categories?post=2620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biology.sdsu.edu\/doctoral\/cell-molecular\/wp-json\/wp\/v2\/tags?post=2620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}